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|Tested species reactivity||Mouse , Human , Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized peptide derived from residues 334-349 of the human ERK5/BMK1 protein. Full-length ERK5/BMK1 has a Mr of ~88 kDa, however, truncated versions of ~30-35 kDa have also been observed.|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||3-5 µg x 10^6 cells|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5. It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
PRKM7, Erk5-T, Prkm7, Bmk1, ERK5, BMK1, Erk5, ERK4, BMK-1, ERK-5
BMK-1, BMK1 kinase, ERK-5, MAP kinase 7, MAPK 7, big MAP kinase 1, extracellular signal-regulated kinase 5, mitogen-activated protein kinase 7, extracellular signal regulated kinase 5, mitogen activated protein kinase 7, extracellular-signal-regulated kinase 5, BNhp-1, BNhp1 kinase