c-Jun amino terminal kinases (JNKs) are MAP kinase family members that differ from other MAP kinases in that they are phosphorylated at the Thr-Pro-Tyr phosphorylation motif instead of the characteristic MAP kinase Thr-Glu-Tyr motif. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53.
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Protein Aliases: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK; JNK-55; JNK1; JNK1A2; JNK21B1/2; Jun kinase; MAP kinase 9; MAPK 10; MAPK 9; MAPK10; MAPK8; Mitogen-activated protein kinase 9; OTTHUMP00000161542; OTTHUMP00000161543; PRKM8; SAPK1; SAPK1a; Stress-activated protein kinase 1a; Stress-activated protein kinase JNK2
Gene Aliases: JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; MAPK9; p54a; p54aSAPK; PRKM9; SAPK; SAPK1A
UniProt ID: (Human) P45984
Entrez Gene ID: (Human) 5601
Molecular Function: non-receptor serine/threonine protein kinase