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OriGene

MAPK9 Monoclonal Antibody (OTI4D1), TrueMAB™

View all (35) JNK2 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

CF505910

Applications Tested Dilution Publications

Western Blot (WB)

 1:200-1:2,000 -

Immunohistochemistry (Paraffin) (IHC (P))

 1:150 -

Immunocytochemistry (ICC/IF)

 1:100 -
Product Specifications

Species Reactivity

 Dog, Human, Mouse

Host/Isotype

 Mouse / IgG1

Class

 Monoclonal

Type

 Antibody

Clone

 OTI4D1

Immunogen

Full length human recombinant protein of human MAPK9 produced in HEK293T cell.
View immunogen

Conjugate

 Unconjugated

Form

 lyophilized

Concentration

 1 mg/mL

Purification

 Affinity chromatography

Storage buffer

 PBS, pH 7.3, with 8% trehalose

Contains

 no preservative

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

c-Jun amino terminal kinases (JNKs) are MAP kinase family members that differ from other MAP kinases in that they are phosphorylated at the Thr-Pro-Tyr phosphorylation motif instead of the characteristic MAP kinase Thr-Glu-Tyr motif. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK; JNK-55; JNK/SAPK alpha; JNK1; JNK1A2; JNK21B1/2; Jun kinase; MAP kinase 9; MAPK 10; MAPK 9; MAPK10; MAPK8; mitogen activated protein kinase 9; Mitogen-activated protein kinase 9; OTTHUMP00000161542; OTTHUMP00000161543; PRKM8; protein kinase, mitogen-activated 9; SAPK1; SAPK1a; Stress-activated protein kinase 1a; Stress-activated protein kinase JNK2

Gene Aliases: AI851083; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; MAPK9; p54a; p54aSAPK; PRKM9; SAPK; SAPK1A

UniProt ID: (Human) P45984, (Mouse) Q9WTU6

Entrez Gene ID: (Human) 5601, (Dog) 474652, (Mouse) 26420

Molecular Function: non-receptor serine/threonine protein kinase

Function(s)
release of cytochrome c from mitochondria positive regulation of protein phosphorylation protein phosphorylation protein targeting to mitochondrion activation of cysteine-type endopeptidase activity involved in apoptotic process response to stress JNK cascade JUN phosphorylation central nervous system development response to mechanical stimulus response to toxic substance positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of cell morphogenesis involved in differentiation response to amine neuron projection development positive regulation of prostaglandin biosynthetic process regulation of protein ubiquitination positive regulation of prostaglandin secretion positive regulation of chemokine production cellular response to UV Fc-epsilon receptor signaling pathway response to drug regulation of circadian rhythm positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated regulation of JNK cascade response to cadmium ion rhythmic process regulation of sequence-specific DNA binding transcription factor activity positive regulation of nitric-oxide synthase biosynthetic process cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to growth factor stimulus positive regulation of podosome assembly positive regulation of apoptotic signaling pathway phosphorylation positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Process(es)
JUN kinase activity protein binding ATP binding transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process mitogen-activated protein kinase kinase kinase binding nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
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