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OriGene

MAPK9 Monoclonal Antibody (OTI4D1), TrueMAB™

View all (22) JNK2 antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
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C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
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C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support

Product Details

Tested Applications
Dilution
Immunocytochemistry (ICC)
1:100
Immunofluorescence (IF)
1:100
Immunohistochemistry (Paraffin) (IHC (P))
1:150
Western Blot (WB)
1:200-1:2000
Product Specifications
Species Reactivity
Dog, Human, Mouse
Host / Isotype
Mouse / IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4D1
Immunogen
Full length human recombinant protein of human MAPK9 produced in HEK293T cell.
Conjugate
Unconjugated
Form
lyophilized
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product # 7KMWCO

Target Information

C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK-55; JNK/SAPK alpha; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; Jun kinase; MAP kinase 9; MAPK 9; mitogen activated protein kinase 9; Mitogen-activated protein kinase 9; p54a; p54aSAPK; PRKM9; protein kinase, mitogen-activated 9; SAPK; SAPK1a; Stress-activated protein kinase 1a; Stress-activated protein kinase JNK2

Gene Aliases: AI851083; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; MAPK9; p54a; p54aSAPK; PRKM9; SAPK; SAPK1A

UniProt ID: (Human) P45984, (Mouse) Q9WTU6

Entrez Gene ID: (Human) 5601, (Dog) 474652, (Mouse) 26420

Molecular Function: kinase non-receptor serine/threonine protein kinase protein kinase transferase

Function(s)
release of cytochrome c from mitochondria positive regulation of protein phosphorylation protein phosphorylation protein targeting to mitochondrion activation of cysteine-type endopeptidase activity involved in apoptotic process response to stress JNK cascade JUN phosphorylation central nervous system development response to mechanical stimulus response to toxic substance positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of cell morphogenesis involved in differentiation response to amine neuron projection development positive regulation of prostaglandin biosynthetic process regulation of protein ubiquitination positive regulation of prostaglandin secretion positive regulation of chemokine production cellular response to UV Fc-epsilon receptor signaling pathway response to drug regulation of circadian rhythm positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated regulation of JNK cascade response to cadmium ion rhythmic process regulation of sequence-specific DNA binding transcription factor activity positive regulation of nitric-oxide synthase biosynthetic process cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to growth factor stimulus positive regulation of podosome assembly positive regulation of apoptotic signaling pathway phosphorylation positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Process(es)
JUN kinase activity protein binding ATP binding transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process mitogen-activated protein kinase kinase kinase binding nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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