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Product Details
H00008550-M02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3D7
Immunogen
MAPKAPK5 (AAH47284, 371 a.a. approximately 471 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: KDSVYIHDHE NGAEDSNVAL EKLRDVIAQC ILPQAGENED EKLNEVMQEA WKYNRECKLL RDTLQSFSWN GRGFTDKVDR LKLAEIVKQV IEEQTTSHES Q
Target Information
MAPKAPK5 (PRAK) is activated in response to cellular stress and pro-inflammatory cytokines. Activity of this kinase is regulated by p38 alpha and p38 beta. The protein encoded by PRAK is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of PRAK encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5; p38-regulated/activated protein kinase; PRAK
Gene Aliases: MAPKAP-K5; MAPKAPK5; MK-5; MK5; PRAK
UniProt ID: (Human) Q8IW41
Entrez Gene ID: (Human) 8550
MAPK cascade
activation of MAPK activity
regulation of translation
signal transduction
Ras protein signal transduction
peptidyl-serine phosphorylation
negative regulation of TOR signaling
positive regulation of telomere maintenance via telomerase
protein autophosphorylation
positive regulation of telomerase activity
stress-induced premature senescence
regulation of signal transduction by p53 class mediator
positive regulation of telomere capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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