|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG1|
|Immunogen||CHO cells expressing mouse MARCO|
|Storage buffer||PBS with 1% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:5-1:10|
|Flow Cytometry (Flow)||See 1 publications below|
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control.
MA5-16661 was used in flow cytometry to study the role of type 1 Interferons produced by spleen red pulp cells in sensing and controlling malarial infection
|Kim CC,Nelson CS,Wilson EB,Hou B,DeFranco AL,DeRisi JL||PloS one (7:null)||2012|
AI323439; Ly112; macrophage receptor MARCO; Scara2
AI323439; Ly112; Marco; Scara2