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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human MATK expressed in E. Coli.|
|Storage buffer||PBS with 50% glycerol|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15553 targets MATK in FACS and WB applications and shows reactivity with Human samples.
The MA5-15553 immunogen is purified recombinant fragment of human MATK expressed in E. Coli.
MA5-15553 detects MATK which has a predicted molecular weight of approximately 56kDa.
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CHK; CSK homologous kinase; Csk-homologous kinase; Csk-type protein tyrosine kinase; CTK; DKFZp434N1212; hematopoietic consensus tyrosine-lacking kinase; HHYLTK; hydroxyaryl-protein kinase; HYL; HYL tyrosine kinase; HYLTK; leukocyte carboxyl-terminal src kinase related; Lsk; MATK; MGC1708; MGC2101; protein kinase HYL; tyrosine kinase MATK; tyrosine-protein kinase CTK; tyrosylprotein kinase
CHK; CTK; HHYLTK; HYL; HYLTK; Lsk; MATK