|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant soluble form of MAdCAM-1-Fc (first Ig domain)|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Functional Assay (FN)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis.
37-5700 was used in immunohistochemistry to observe the subcortical bone marrow changes in joints from patients with rheumatoid arthritis
|Jimenez-Boj E,Redlich K,Türk B,Hanslik-Schnabel B,Wanivenhaus A,Chott A,Smolen JS,Schett G||Journal of immunology (Baltimore, Md. : 1950) (175:2579)||2005|
|Human||Not Cited||Bioassay detects soluble MAdCAM-1 in body fluids.||Leung E,Lehnert KB,Kanwar JR,Yang Y,Mon Y,McNeil HP,Krissansen GW||Immunology and cell biology (82:400)||2004|