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Immunogen sequence: GTELAETELP NDVQSTSSVL CAHTEKKDKA KEDLRLALKE GHSVLESLRE LQAEGSEPSV NQDQLDNQAT VQRLLAQLNE TEAAFDEFWA KHQQKLEQCL
This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants.
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Protein Aliases: DBL's big sister; FLJ12122; Guanine nucleotide exchange factor DBS; MCF2 transforming sequence-like protein; MCF2-transforming sequence-like protein; RP11-98F14.2
Gene Aliases: ARHGEF14; DBS; KIAA0362; MCF2L; OST
UniProt ID: (Human) O15068
Entrez Gene ID: (Human) 23263
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