MA5-15236 targets MCL-1 in IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15236 immunogen is purified recombinant fragment of human MCL-1 expressed in E. Coli.
MA5-15236 detects MCL-1 which has a predicted molecular weight of approximately 37kDa.
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products promote apoptosis and are death-inducing.
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Protein Aliases: Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; Bcl2-L-3; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; mcl1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related)
Gene Aliases: bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM
UniProt ID: (Human) Q07820
Entrez Gene ID: (Human) 4170
Molecular Function: signaling molecule