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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to a portion of human Minichromosome Maintenance Deficient 6 encoded by exon 17.|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris phosphate/tris citrate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:2000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-26584 detects MCM6 from human samples. PA1-26584 is expected to cross react with mouse and rat (both 97% conserved) due to sequence homology.
PA1-26584 has been successfully used in Western blot procedures.
The PA1-26584 immunogen is a synthetic peptide corresponding to a portion of human Minichromosome Maintenance Deficient 6 encoded by exon 17.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DNA replication licensing factor MCM6; intestinal DNA replication protein; MCG40308; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe); mini chromosome maintenance deficient 6; minichromosome maintenance deficient (mis5, S. pombe) 6; minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe); Mis5; Mis5 homolog; P105MCM
ASP-l1; D1Wsu22e; MCG40308; MCM6; Mcmd6; Mis5; P105MCM