Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes.
Erlichman N,Baram T,Meshel T,Morein D,Da'adoosh B,Ben-Baruch A
500-M71 was used in Enzyme-linked immunosorbent assay to investigate the role of WT-PD-L1 in triple-negative breast cancer.
Fri Feb 18 00:00:00 EST 2022
Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer.
Frontiers in immunology
Liubomirski Y,Lerrer S,Meshel T,Rubinstein-Achiasaf L,Morein D,Wiemann S,Körner C,Ben-Baruch A
500-M71 was used in Enzyme-linked immunosorbent assay to study the impact of tumor-stroma-inflammation networks on pro-metastatic phenotypes in triple-negative breast cancer (TNBC) to identify a novel tumor-stroma-inflammation networks that may promote TNBC aggressiveness by increasing the pro-malignancy potential of the TME and of the tumor cells themselves, and reveal key roles for CXCL8 in mediating these metastasis-promoting activities.
Mon Aug 10 00:00:00 EDT 2020
Co-Inflammatory Roles of TGFβ1 in the Presence of TNFα Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells.
Frontiers in immunology
Lerrer S,Liubomirski Y,Bott A,Abnaof K,Oren N,Yousaf A,Körner C,Meshel T,Wiemann S,Ben-Baruch A
500-M71 was used in Enzyme-linked immunosorbent assay to demonstrate a TNFα + TGFβ1-driven pro-inflammatory fate in MSCs, identify specific molecular mechanisms involved, and propose that TNFα + TGFβ1-stimulated MSCs influence the tumor niche.
Wed Nov 20 00:00:00 EST 2019
M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration.
Journal of leukocyte biology
Barzilai S,Blecher-Gonen R,Barnett-Itzhaki Z,Zauberman A,Lebel-Haziv Y,Amit I,Alon R
500-M71 was used in Enzyme-linked immunosorbent assay to the first evidence of a novel inflammation-inducible machinery that regulates polarized secretion of endothelial CCL2 and other inflammatory chemokines and cytokines into basolateral endothelial compartments and facilitates the ability of endothelial CCL2 to promote T cell transendothelial migration.
Wed Jun 01 00:00:00 EDT 2016
Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway.
Stem cell research & therapy
Katanov C,Lerrer S,Liubomirski Y,Leider-Trejo L,Meshel T,Bar J,Feniger-Barish R,Kamer I,Soria-Artzi G,Kahani H,Banerjee D,Ben-Baruch A
500-M71 was used in Enzyme-linked immunosorbent assay to study the impact of tumour necrosis factor α and interleukin 1β on the inflammatory phenotype of cancer-associated fibroblasts and mesenchymal stem cells.
Fri May 01 00:00:00 EDT 2015
Breast cancer: coordinated regulation of CCL2 secretion by intracellular glycosaminoglycans and chemokine motifs.
Neoplasia (New York, N.Y.)
Lebel-Haziv Y,Meshel T,Soria G,Yeheskel A,Mamon E,Ben-Baruch A
500-M71 was used in Immunocytochemistry-immunoflourescence to propose that targeting these chemokine regions may lead to reduced secretion of CCL2 by breast cancer cells (and potentially also by other malignant cells).
Mon Sep 01 00:00:00 EDT 2014
Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment.
Mediators of inflammation
Weitzenfeld P,Meron N,Leibovich-Rivkin T,Meshel T,Ben-Baruch A
500-M71 was used in Enzyme-linked immunosorbent assay to indicate that TNF α can turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNFα would be applied in breast cancer therapy.
Thu Jun 05 00:00:00 EDT 2014
The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.
Leibovich-Rivkin T,Liubomirski Y,Meshel T,Abashidze A,Brisker D,Solomon H,Rotter V,Weil M,Ben-Baruch A
500-M71 was used in Enzyme-linked immunosorbent assay to determine the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly expressed in tumors of >80% of breast cancer patients with recurrent disease.
Thu Mar 06 00:00:00 EST 2014
Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells: EMT, invasion, and collapse of normally organized breast textures.
Neoplasia (New York, N.Y.)
Leibovich-Rivkin T,Liubomirski Y,Bernstein B,Meshel T,Ben-Baruch A
500-M71 was used in Enzyme-linked immunosorbent assay to reveal novel pathways through which the inflammatory microenvironment may contribute to relapsed disease in breast cancer.
Sun Dec 01 00:00:00 EST 2013
Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations.
Leibovich-Rivkin T,Buganim Y,Solomon H,Meshel T,Rotter V,Ben-Baruch A
500-M71 was used in Enzyme-linked immunosorbent assay to use an unbiased model system to propose that inflammatory mediators of the tumor milieu have dominating roles over oncogenic modifications in dictating the expression of a pro-malignancy chemokine readout.
Fri Jan 20 00:00:00 EST 2012
Endogenous CCL2 (monocyte chemotactic protein-1) modulates human immunodeficiency virus type-1 replication and affects cytoskeleton organization in human monocyte-derived macrophages.
Fantuzzi L,Spadaro F,Vallanti G,Canini I,Ramoni C,Vicenzi E,Belardelli F,Poli G,Gessani S
Wed Oct 01 00:00:00 EDT 2003
Identification of human complement factor H as a chemotactic protein for monocytes.
The Biochemical journal
Nabil K,Rihn B,Jaurand MC,Vignaud JM,Ripoche J,Martinet Y,Martinet N
500-M71 was used in neutralization assay.
Mon Sep 01 00:00:00 EDT 1997
Production of monocyte chemoattractant protein-1 by bovine glomerular endothelial cells.
Kakizaki Y,Waga S,Sugimoto K,Tanaka H,Nukii K,Takeya M,Yoshimura T,Yokoyama M
Fri Dec 01 00:00:00 EST 1995