Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
MCP-2 (monocyte chemoattractant protein 2) belongs to the CC chemokine family. MCPs are chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. It is induced by IFN-gamma, mitogens, and IL1/interleukin-1. MCP-2 specifically attracts monocytes, but not neutrophils. High levels of MCP-2 are found in the small intestine, and peripheral blood cells. Intermediate levels are seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord, and pancreas. Low levels are seen in the brain, liver, spleen, and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C motif chemokine 8; chemokine (C-C motif) ligand 8; HC14; MCP-2; MCP-2(6-76); Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; SCYA10; SCYA8; small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2); Small-inducible cytokine A8
Gene Aliases: CCL8; HC14; MCP-2; MCP2; SCYA10; SCYA8
UniProt ID: (Human) P80075
Entrez Gene ID: (Human) 6355