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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||Recombinant MCPH1 polypeptides|
|Contains||0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Gel Shift (GS)||See 1 publications below|
This antibody recognizes the region within amino acids 1-83 of MCPH1/BRIT1.
This protein is implicated in chromosome condensation and DNA damage induced cellular responses, and may play a role in neurogenesis and regulation of the size of the cerebral cortex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
MCPH1 maintains long-term epigenetic silencing of ANGPT2 in chronic lymphocytic leukemia.
MA5-18057 was used in ChIP assay, EMSA, and immunoprecipitation to investigate the functional role of MCPH1 in regulation of ANGPT2 in chronic lymphocytic leukemia
|Kopparapu PK,Miranda C,Fogelstrand L,Mishra K,Andersson PO,Kanduri C,Kanduri M||The FEBS journal (282:1939)||2015|
BRCT-repeat inhibitor of TERT expression 1; FLJ12847; truncated microcephalin
BRIT1; MCPH1; MCT