Immunogen sequence: HPDAFYLART AKALQAHWQL MKQYYLLEDQ TVQPLPKGDQ VLNFSDAEDL IDDSKLKDMR DEVLEHELMV ADRRQKREIR QLEQELHKWQ VLVD
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.
Protein Aliases: 58 kDa microspherule protein; cell cycle-regulated factor (78 kDa); Cell cycle-regulated factor p78; INO80 complex subunit J; INO80 complex subunit Q; MCRS2; Microspherule protein 1; nucleolar protein
Gene Aliases: C78274; ICP22BP; INO80Q; MCRS1; MCRS2; MSP58; P78