|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide - Immunogen sequence information is commercially sensitive.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 2% sucrose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-27958 detects MDM4 from human samples.
PA1-27958 may be successfully used in Western blot applications. Use at a concentration of 1µg/ml in 5% skim milk/PBS buffer.
The PA1-27646 immunogen is a synthetic peptide with a commercially sensitive sequence.
MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apotopic functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.