|ELISA (ELISA)||0.1-1.0 ug/ml|
|Immunofluorescence (IF)||15-20 ug/ml|
|Western Blot (WB)||1-3 ug/ml|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Dog, Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant GST-fusion protein containing full length human MKK7 sequence.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; Jnkk2; MAP kinase kinase 7; map2k7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; mitogen activated protein kinase kinase 7; MKK7; PRKMK7; protein kinase, mitogen activated, kinase 7; SAPK kinase 4; SAPKK-4; SAPKK4; Stress-activated protein kinase kinase 4
Gene Aliases: 5930412N11Rik; JNKK 2; JNKK2; MAP2K7; MAPKK 7; MAPKK7; MEK; MEK 7; MEK7; MKK7; PRKMK7; SAPKK-4; SAPKK4; sek2; SKK4
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.