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|Tested species reactivity||Dog, Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant GST-fusion protein containing full length human MKK7 sequence.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.1-1.0 ug/ml|
|Immunofluorescence (IF)||15-20 ug/ml|
|Western Blot (WB)||1-3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Mouse||Not Cited||Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).||Kelkar N,Delmotte MH,Weston CR,Barrett T,Sheppard BJ,Flavell RA,Davis RJ||Proceedings of the National Academy of Sciences of the United States of America (100:9843)||2003|
c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; Jnkk2; MAP kinase kinase 7; map2k7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; mitogen activated protein kinase kinase 7; MKK7; PRKMK7; protein kinase, mitogen activated, kinase 7; SAPK kinase 4; SAPKK-4; SAPKK4; stress-activated protein kinase kinase 4
5930412N11Rik; JNKK 2; JNKK2; MAP2K7; MAPKK 7; MAPKK7; MEK; MEK 7; MEK7; MKK7; PRKMK7; SAPKK-4; SAPKK4; sek2; SKK4