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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 38 and 396 of Human MEK7|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27922 targets MEK7 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27922 immunogen is recombinant fragment corresponding to a region within amino acids 38 and 396 of Human MEK7.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7; JNK-activating kinase 2; JNKK 2; Jnkk2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; MKK7; PRKMK7; SAPK kinase 4; SAPKK-4; SAPKK4; stress-activated protein kinase kinase 4
JNKK2; MAP2K7; MAPKK7; MEK; MEK 7; MEK7; MKK7; PRKMK7; SAPKK-4; SAPKK4; SKK4