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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (22 CRPALSLQETRKAKSSSPKKKQN 41) of MEKK2 protein.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MEKK2 is a serine/threonine protein kinase, belonging to the MAP (mitogen-activated protein) kinase family. It plays an important role in activation of MAPK and preferentially activates other kinases involved in the MAP kinase signaling pathway. MEKK2 is known to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. It regulates T-cell function, controls cytokine gene expression in mast cells, mediates epidermal growth factor (EGF) receptor and fibroblast growth factor-2 (FGF-2) receptor signals,and plays a role in rheumatoid arthritis. It is also involved in LPS–TLR4 signaling, due to its phosphorylation by TLR4 ligand, LPS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
MAP/ERK kinase kinase 2; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; MEKK2; MEKK2B
MAP3K2; MAPKKK2; MEKK2; MEKK2B