Sequence of this protein is as follows: MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF ASQHHRGHHH HHHHHHHHHQ QQQHQALQTN WHLPQMSSPP SAARHSLCLQ PDSGGPPELG SSPPVLCSNS SSLGSSTPTG AACAPGDYGR QALSPAEAEK RSGGKRKSDS SDSQEGNYKS EVNSKPRKER TAFTKEQIRE LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK WKRVKGGQQG AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSIANED SHDSDHSSEH AHL
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Growth arrest-specific homeobox; Homeobox protein MOX-2; mesenchyme homeo box 2 (growth arrest-specific homeo box); Mesenchyme homeobox 2
Gene Aliases: AI528662; GAX; MEOX2; Mox-2; MOX2