MA5-17121 targets MESP2 in pep-ELISA and WB applications and shows reactivity with Human samples.
The MA5-17121 immunogen is purified recombinant fragment of human MESP2 (amino acids: 37-94 ) expressed in E. Coli.
MA5-17121 detects MESP2 which has a predicted molecular weight of approximately 41.8kDa.
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
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Protein Aliases: bHLHc6; Class C basic helix-loop-helix protein 6; mesoderm posterior 2 homolog; mesoderm posterior basic helix-loop-helix transcription factor 2; Mesoderm posterior protein 2
Gene Aliases: BHLHC6; MESP2; SCDO2
UniProt ID: (Human) Q0VG99
Entrez Gene ID: (Human) 145873