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Invitrogen
METTL15P1 Recombinant Mouse Monoclonal Antibody (K1H006_6E6)
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FIGURE: 1 / 1
METTL15P1 Antibody (MA564504) in WB
Western blot analysis of METTL15P1 in mouse testis tissue lysate (15 µg). Samples were incubated with METTL15P1 recombinant monoclonal (Product # MA564504) using a dilution of 1 µg/mL followed by peroxidase conjugated goat anti-mouse IgG. Sample was run on 6-18% SDS-PAGE under reducing conditions and blotted onto nitrocellulose membrane. METTL15P1 band was visualized using ECL Western Blotting Substrate.
Product Details
MA564504
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
K1H006_6E6
Immunogen
Recombinant human METTL15P1 (aa 51-200).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QTQVQELHRS QDRDFETMAK LHIPVMVDEV VHCLSPQKGQ IFLDMTFGSG GHTKAILQKE SDIVLYALDR DPTAYALAEH LSELYPKQIR AMLGQFSQAE ALLMKAGVQP GTFDGVLMDL GCSSMQLDTP ERGSSLRKDG PLDIRMDGGR
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Pig - 87%, Cynomolgus monkey - 96%.
Target Information
METTL15P1 is a pseudogene related to the METTL15 gene, which encodes a methyltransferase responsible for methylation of mitochondrial 12S rRNA at m4C839 both in vivo and in vitro. The METTL15 protein is involved in fine-tuning gene expression, particularly during differentiation processes in cells, as part of the METTL3-METTL14-DNMT1 axis, which is crucial for regulating expression of key differentiation genes in embryonic stem cells. Additionally, METTL15 is linked to the regulation of the mitochondrial genome, influencing stress-specific responses and contributing to an information-rich genotype-phenotype map that elucidates gene function and cellular dynamics. While pseudogenes like METTL15P1 do not encode functional proteins, they may still play roles in gene regulation and the broader genomic context. The study of METTL15P1 could potentially reveal insights into the evolutionary history of RNA methylation and its impact on cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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