|Flow Cytometry (Flow)||Assay Dependent|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b, kappa|
|Immunogen||mouse major histocompatibility complex class II molecules, both I-A and I-E subregion-encoded glycoproteins.|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H-2 class II histocompatibility antigen A beta chain; H-2 class II histocompatibility antigen, A beta chain; H2-AB1; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; major histocompatibility complex class II beta chain; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1
Gene Aliases: Abeta; AI845868; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2; IAb; Rmcs1
UniProt ID: (Mouse) P14483
Entrez Gene ID: (Mouse) 14961
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