This clone recognizes SLA DR molecules expressed on all B cells, antigen presenting cells and on certain subsets of resting and activated T cells. It reacts with lymphocytes from all outbred and miniature pigs so far tested, suggesting that it recognizes a monomorphic determinant of porcine SLA DR. This antibody will cross-react with bovine samples.
MA5-16513 immunoprecipitates a heterodimer composed of two polypeptides of ~28 and ~35 kDa from NP-40 extracts of biotin surface-labelled porcine peripheral blood mononuclear cells. It has been reported to inhibit the mixed lymphocyte reaction and T cell stimulation induced by African swine fever virus and staphylococcal enterotoxin B.
The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections.
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Protein Aliases: MHC 1 Monomorphic; MHC Class 1 Monomorphic; MHC Class I Monomorphic