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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant human CD74 protein|
|Storage buffer||PBS, pH 7.6, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
|Western Blot (WB)||1:25|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is tonsil tissue.
Expression of the invariant chain of the HLA-DR antigen (CD74) by B-lymphocytes begins in the pre-B stage but lost before the final differentiation to plasma cells. This protein is expressed in B-lymphocytes and many B-cell lymphomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; DHLAG; gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; HLADG; Ia antigen-associated invariant chain; Ia-associated invariant chain; IA-gamma; Ii; MHC HLA-DR gamma chain; p33
CD74; DHLAG; HLADG; Ia-GAMMA; II