MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
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Protein Aliases: 53 kDa; 60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; Histone lysine demethylase MINA; MDIG; MINA; MINA53; mineral dust induced gene protein; Mineral dust-induced gene protein; MYC-induced nuclear antigen; myc-induced nuclear antigen, 53 kDa; NO52; Nucleolar protein 52; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; ROX
Gene Aliases: MDIG; MINA; MINA53; NO52; RIOX2; ROX
UniProt ID: (Human) Q8IUF8
Entrez Gene ID: (Human) 84864