MA5-15925 targets MAP2K7 in FACS, IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15925 immunogen is purified recombinant fragment of human MAP2K7 expressed in E. Coli. .
MA5-15925 detects MAP2K7 which has a predicted molecular weight of approximately 48kDa.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
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Protein Aliases: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; Jnkk2, MAPKK7, MKK7, PRKMK7, SAPKK-4, SAPKK4, JNK-activating kinase 2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MEK 7; SAPK kinase 4; SAPKK-4; SAPKK4; Stress-activated protein kinase kinase 4
Gene Aliases: JNKK2; MAP2K7; MAPKK7; MEK; MEK 7; MEK7; MKK7; PRKMK7; SAPKK-4; SAPKK4; SKK4
UniProt ID: (Human) O14733
Entrez Gene ID: (Human) 5609