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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human protein purified from E.coli (His-MKP4)|
|Purification||Ammonium sulfate precipitation|
|Storage buffer||HEPES with 0.15M NaCl, 0.01% BSA, 50% glycerol|
|Contains||0.03% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for this product is HepG2 cells.
There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP4 (DUSP9) is a dual specificity phosphatase, which acts as a negative regulator of insulin-stimulated pathways. MKP4 is expressed in kidney, placenta and adipose tissue. MKP4, a cytosolic MKP with specificity to not only Erk, but also, to a lesser extent, JNK and p38. MKP4 also reversed the effect of TNF-a to inhibit insulin Signaling. MKP4 has a protective effect against the development of insulin resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
dual specificity protein phosphatase 9; map kinase phosphatase 4; mitogen-activated protein kinase phosphatase 4; MKP-4; MKP4; serine/threonine specific protein phosphatase
DUSP9; MKP-4; MKP4