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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant full length protein (Human).|
|Storage buffer||0.05M sodium phosphate with 0.2% gelatin|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||9-11 µg/ml|
|Western Blot (WB)||1-1.5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-90218 detects MLH1 from human samples.
MA1-90218 has been successfully used in immunohistochemistry (paraffin tissue), Western blot applications.
The MA1-90218 immunogen is: Recombinant full length protein (Human).
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MGC5172; mutL homolog 1, colon cancer, nonpolyposis type 2
COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MLH1