|Tested species reactivity||Human|
|Published species reactivity||Dog, Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant protein corresponding to active form of human MMP-11|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:200 - 400|
|Immunoprecipitation (IP)||2 µg/ml|
|Western Blot (WB)||0.5-1.0 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11231 targets MMP-11 (Stromelysin-3) in IHC (P), IP, and WB applications and shows reactivity with Human samples.
The MA5-11231 immunogen is recombinant protein corresponding to active form of human MMP-11.
Stromelysin, a member of the matrix metalloproteinase family, demonstrates wide substrate specificity with the ability to degrade proteoglycan, fibronectin, laminin, casein, and the nonhelical region of collagen. The stromelysin-3 (MMP-11) gene was originally identified on the basis that it is expressed specifically in stromal cells surrounding invasive breast carcinomas. MMP-11 is localized by in situ hybridization to the long arm of chromosome 22. The MMP-11 expression is found more specifically in malignant tumors than in benign ones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Axillary basal cell carcinoma--a rare form of a frequent kind of carcinoma.
MA5-11231 was used in immunohistochemistry to study axillary basal cell carcinoma
|Costescu M,Coman OA,Tampa M,Tudose I,Coman L,Georgescu SR||Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (54:851)||2013|
Low microvascular density at the tumor center is related to the expression of metalloproteases and their inhibitors and with the occurrence of distant metastasis in breast carcinomas.
MA5-11231 was used in immunohistochemistry to study the relationship between tumor microvascular density and the expression of MMPs and TIMPs in breast carcinoma and the significance for distant metastasis
|Fernández-Guinea O,Álvarez-Cofiño A,Eiró N,González LO,del Casar JM,Fernandez-Garcia B,Lamelas ML,Andicoechea A,Vizoso FJ||International journal of clinical oncology (18:629)||2013|
Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene.
MA5-11231 was used in immunohistochemistry to examine the role of Foxf1 in pulmonary mastocytosis and lung inflammation
|Kalin TV,Meliton L,Meliton AY,Zhu X,Whitsett JA,Kalinichenko VV||American journal of respiratory cell and molecular biology (39:390)||2008|
Differential expression of prognostic markers in histological subtypes of papillary renal cell carcinoma.
MA5-11231 was used in immunohistochemistry to examine the prognostic significance of tumor markers in papillary renal cell carcinoma
|Perret AG,Clemencon A,Li G,Tostain J,Peoc'h M||BJU international (102:183)||2008|
Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis.
MA5-11231 was used in immunohistochemistry to study the phase-dependent expression of MMPs and TIMPs in demyelinating canine distemper encephalitis
|Miao Q,Baumgärtner W,Failing K,Alldinger S||Acta neuropathologica (106:486)||2003|
Matrix metalloprotease activity is an essential link between mechanical stimulus and mesenchymal stem cell behavior.
MA5-11231 was used in western blot to investigate the expression levels of matrix metalloproteases in mesenchymal stem cell and their roles in mesenchymal stem cell behavior
|Kasper G,Glaeser JD,Geissler S,Ode A,Tuischer J,Matziolis G,Perka C,Duda GN||Stem cells (Dayton, Ohio) (25:1985)||2007|