|Tested species reactivity||Human|
|Published species reactivity||Dog, Human, Mouse, Not Applicable|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant protein corresponding to active form of human MMP-11|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:200-1:400|
|Immunoprecipitation (IP)||2 µg/ml|
|Western Blot (WB)||0.5-1.0 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11234 targets MMP-11 (Stromelysin-3) in IHC (P), IP, and WB applications and shows reactivity with Human samples.
The MA5-11234 immunogen is recombinant protein corresponding to active form of human MMP-11.
Stromelysin, a member of the matrix metalloproteinase family, demonstrates wide substrate specificity with the ability to degrade proteoglycan, fibronectin, laminin, casein, and the nonhelical region of collagen. The stromelysin-3 (MMP-11) gene was originally identified on the basis that it is expressed specifically in stromal cells surrounding invasive breast carcinomas. MMP-11 is localized by in situ hybridization to the long arm of chromosome 22. The MMP-11 expression is found more specifically in malignant tumors than in benign ones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Axillary basal cell carcinoma--a rare form of a frequent kind of carcinoma.
MA5-11234 was used in immunohistochemistry to study axillary basal cell carcinoma
|Costescu M,Coman OA,Tampa M,Tudose I,Coman L,Georgescu SR||Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (54:851)||2013|
Immunoexpression of matrix metalloproteinases and their inhibitors in different areas of oral squamous cell carcinoma.
MA5-11234 was used in immunohistochemistry to study the expression of MMPs and TIMPs in different histopathological regions of oral squamous cell carcinomas
|Suarez-Roa ML,Asbun-Bojalil J,Ruiz-Godoy LM,Meneses-García AA||Australian dental journal (57:300)||2012|
Effect of the expression of matrix metalloproteases and their tissue inhibitors on survival of patients with resectable colorectal cancer.
MA5-11234 was used in immunohistochemistry to study the expression and clinical relevance of MMPs and TIMPs in patients with resectable colorectal carcinoma
|González L,Eiró N,González LO,Andicoechea A,Barbón E,García-Muñiz JL,Vizoso FJ||Digestive diseases and sciences (57:2063)||2012|
Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene.
MA5-11234 was used in immunohistochemistry to examine the role of Foxf1 in pulmonary mastocytosis and lung inflammation
|Kalin TV,Meliton L,Meliton AY,Zhu X,Whitsett JA,Kalinichenko VV||American journal of respiratory cell and molecular biology (39:390)||2008|
Differential expression of prognostic markers in histological subtypes of papillary renal cell carcinoma.
MA5-11234 was used in immunohistochemistry to examine the prognostic significance of tumor markers in papillary renal cell carcinoma
|Perret AG,Clemencon A,Li G,Tostain J,Peoc'h M||BJU international (102:183)||2008|
Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis.
MA5-11234 was used in immunohistochemistry to study the phase-dependent expression of MMPs and TIMPs in demyelinating canine distemper encephalitis
|Miao Q,Baumgärtner W,Failing K,Alldinger S||Acta neuropathologica (106:486)||2003|
Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
MA5-11234 was used in western blot to study the effects of Ranbp2 conditional knockout in cone photoreceptors on the activation of cell death pathways
|Cho KI,Haque M,Wang J,Yu M,Hao Y,Qiu S,Pillai IC,Peachey NS,Ferreira PA||PLoS genetics (9:null)||2013|
Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ER¿ negative breast cancer cell lines.
MA5-11234 was used in western blot to study the mechanism by which Gli1 enhances invasion and promotes metastasis in estrogen receptor alpha-negative breast cancer cell lines
|Kwon YJ,Hurst DR,Steg AD,Yuan K,Vaidya KS,Welch DR,Frost AR||Clinical and experimental metastasis (28:437)||2011|
Matrix metalloprotease activity is an essential link between mechanical stimulus and mesenchymal stem cell behavior.
MA5-11234 was used in western blot to investigate the expression levels of matrix metalloproteases in mesenchymal stem cell and their roles in mesenchymal stem cell behavior
|Kasper G,Glaeser JD,Geissler S,Ode A,Tuischer J,Matziolis G,Perka C,Duda GN||Stem cells (Dayton, Ohio) (25:1985)||2007|