|Inhibition Assays (IA)||2-4 µg/ml|
|Western Blot (WB)||0.5-1.0 µg/ml|
|Immunohistochemistry (IHC)||See 13 publications below|
|Western Blot (WB)||See 6 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Neutralization (Neu)||See 2 publications below|
|Tested Species reactivity||Human, Mouse, Rat|
|Published species reactivity||Dog , Rat , Human , Mouse Chicken|
|Host / Isotype||Mouse / IgG1|
|Clone||CA-4001 or CA719E3C|
|Immunogen||N-terminal peptide APSPIIKFPGD-VAPKTDK of procollagenase IV|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-13590 targets MMP-2 (72kDa Collagenase IV) in IA and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-13590 immunogen is n-terminal peptide APSPIIKFPGD-VAPKTDK of procollagenase IV.
MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play a significant role in regulating angiogenesis. MMP-2; also known as 72kDa collagenase IV or gelatinase A is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids into an active form.of 62kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 72 kDa gelatinase; 72 kDa type IV collagenase; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; collagenase type IV-A; Gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase 2; Matrix metalloproteinase-2; matrix metalloproteinase-II; MMP-2; neutrophil gelatinase; TBE-1
Gene Aliases: CLG4; CLG4A; GelA; MMP-2; MMP-II; MMP2; MONA; TBE-1
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