|Tested species reactivity||Bovine, Human, Mouse, Rat|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide from the second half of human MMP-2|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Western Blot (WB)||5-10 µg/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
PA5-16504 targets MMP-2 (72kDa Collagenase IV) in WB applications and shows reactivity with mouse, Rat, Bovine, and Human samples.
The PA5-16504 immunogen is a synthetic peptide from the second half of human MMP-2.
MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play a significant role in regulating angiogenesis. MMP-2; also known as 72kDa collagenase IV or gelatinase A is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Matrix metalloproteinases 2 and 9 and e-cadherin expression in the endometrium during the implantation window of infertile women before in vitro fertilization treatment.
PA5-16504 was used in immunohistochemistry to study the implantation window expression of endometrial MMP-2, MMP-9 and E-cadherin in infertile woman prior to the initiation of IVF treatment
|Maia-Filho VO,Rocha AM,Ferreira FP,Bonetti TC,Serafini P,Motta EL||Reproductive sciences (Thousand Oaks, Calif.) (22:416)||2015|