|Tested species reactivity||Human, Rat|
|Published species reactivity||Dog, Rat, Human, Mouse, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant Human MMP-9 (native, 92 kDa)|
|Storage buffer||PBS, pH 7.4|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MS817PABX targets MMP-9 in IP, and WB applications and shows reactivity with Human, and Rat samples.
The MS817PABX immunogen is recombinant Human MMP-9 (native, 92 kDa).
MS817PABX detects MMP-9 which has a predicted molecular weight of approximately 1 kDa.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The pattern of CD44 and matrix metalloproteinase 9 expression is a useful predictor of ulcerative colitis-associated dysplasia and neoplasia.
MS817PABX was used in immunohistochemistry - paraffin section to examine CD44 and MMP-9 expression in different ulcerative colitis lesions
|AbdElazeem MA,El-Sayed M||Annals of diagnostic pathology (19:369)||2015|
|Not Applicable||Not Cited||
Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke.
MS817PABX was used in western blot to develop an immunocapture assay to quantify endogenously active MMP-9 activity
|Hawkins KE,DeMars KM,Yang C,Rosenberg GA,Candelario-Jalil E||Molecular brain (6:null)||2013|
Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts.
MS817PABX was used in western blot to study the effects of fibroblasts on mammary carcinoma cells.
|Olsen CJ,Moreira J,Lukanidin EM,Ambartsumian NS||BMC cancer (10:null)||2010|
Cardosins improve neuronal regeneration after cell disruption: a comparative expression study.
MS817PABX was used in western blot to study the use of the plant enzyme cardosin for tissue disaggregation and isolation of rat embryonic neurons
|Duarte AS,Duarte EP,Correia A,Pires E,Barros MT||Cell biology and toxicology (25:99)||2009|
Improved surgical mesh integration into the rat abdominal wall with arginine administration.
MS817PABX was used in western blot to study the role of arginine administration in improving surgical mesh integration into the rat abdominal wall
|Arbos MA,Ferrando JM,Quiles MT,Vidal J,López-Cano M,Gil J,Manero JM,Peña J,Huguet P,Schwartz-Riera S,Reventós J,Armengol M||Biomaterials (27:758)||2006|
Simvastatin suppresses experimental aortic aneurysm expansion.
MS817PABX was used in western blot to study the therapeutic benefits of simvastatin against experimental aortic aneurysm expansion
|Kalyanasundaram A,Elmore JR,Manazer JR,Golden A,Franklin DP,Galt SW,Zakhary EM,Carey DJ||Journal of vascular surgery (43:117)||2006|
Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells.
MS817PABX was used in western blot to study the effect of gamma-synuclein overexpression on MMPs in retinoblastoma cells
|Surgucheva IG,Sivak JM,Fini ME,Palazzo RE,Surguchov AP||Archives of biochemistry and biophysics (410:167)||2003|
In vivo effects of zoledronic acid on oral mucosal epithelial cells.
MS817PABX was used in immunohistochemistry to investigate the influence of zoledronic acid on oral mucosal epithelial cells in a dog model
|Allam E,Allen M,Chu TM,Ghoneima A,Jack Windsor L||Oral diseases (17:291)||2011|
Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model.
MS817PABX was used in immunohistochemistry to study vascular remodeling in a hypomorphic Pkd1(nl/nL) mouse model with dissecting aneurysms in the aorta
|Hassane S,Claij N,Lantinga-van Leeuwen IS,Van Munsteren JC,Van Lent N,Hanemaaijer R,Breuning MH,Peters DJ,DeRuiter MC||Arteriosclerosis, thrombosis, and vascular biology (27:2177)||2007|
Time course of matrix metalloproteases and tissue inhibitors in bleomycin-induced pulmonary fibrosis.
MS817PABX was used in immunohistochemistry to investigate the distribution, expression and activity of matrix metalloproteases and tissue inhibitors during extracellular matrix remodeling in pulmonary fibrosis
|Oggionni T,Morbini P,Inghilleri S,Palladini G,Tozzi R,Vitulo P,Fenoglio C,Perlini S,Pozzi E||European journal of histochemistry : EJH (50:317)||2007|
Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease.
MS817PABX was used in immunohistochemistry to investigate the expression and the role of matrix metalloproteinases in intestinal fistulae
|Kirkegaard T,Hansen A,Bruun E,Brynskov J||Gut (53:701)||2004|
Biological and clinical relevance of matrix metalloproteinases 2 and 9 in acute myeloid leukaemias and myelodysplastic syndromes.
MS817PABX was used in immunocytochemistry to study the biological and clinical relevance of MMP2 and MMP9 in acute myeloid leukaemias and myelodysplastic syndromes
|Travaglino E,Benatti C,Malcovati L,Della Porta MG,Gallì A,Bonetti E,Rosti V,Cazzola M,Invernizzi R||European journal of haematology (80:216)||2008|