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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Clone||F15 P3 B6|
|Immunogen||Synthetic peptide corresponding to residues C(366) S S F G F P R T V K H(376) of human MMP-1.|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-771 contains 100 ug of in vitro produced, protein A purified antibody (1 mg/ml) in PBS containing 1 mg/ml BSA and 0.05% sodium azide.
MA1-771 detects MMP-1 from human samples.
MA1-771 has been successfully used in Western blot applications. By Western blot, MA1-771 detects a ~50 kDa band representing MMP-1 from A431 and K562 cell lysates.
The MA1-771 immunogen is a synthetic peptide corresponding to residues C(366) S S F G F P R T V K H(376) of human MMP-1.
The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
fibroblast collagenase; matrix metallopeptidase 1 (interstitial collagenase); matrix metalloprotease 1; matrix metalloproteinase 1
CLG; CLGN; MMP1