MA5-11231 targets MMP-11 (Stromelysin-3) in IHC (P), IP, and WB applications and shows reactivity with Human samples.
The MA5-11231 immunogen is recombinant protein corresponding to active form of human MMP-11.
Stromelysin, a member of the matrix metalloproteinase family, demonstrates wide substrate specificity with the ability to degrade proteoglycan, fibronectin, laminin, casein, and the nonhelical region of collagen. The stromelysin-3 (MMP-11) gene was originally identified on the basis that it is expressed specifically in stromal cells surrounding invasive breast carcinomas. MMP-11 is localized by in situ hybridization to the long arm of chromosome 22. The MMP-11 expression is found more specifically in malignant tumors than in benign ones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: matrix metallo protease; matrix metallopeptidase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP; MMP-11; MMPs; SL-3; stromelysin III; Stromelysin-3
Gene Aliases: MMP11; SL-3; ST3; STMY3
UniProt ID: (Human) P24347
Entrez Gene ID: (Human) 4320