|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide derived from the c-terminus of the human MMP-9 protein.|
|Contains||0.08% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1 - 5 ug/ml|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Antigen retrieval is required for tissue staining: use 10mM citrate buffer and microwave method. A suggested positive control for this product is colon, esophageal or gastric tissues.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas.
MA1-12894 was used in immunohistochemistry - paraffin section to study the clinical significance and expression of metalloproteases and their inhibitors in invasive breast carcinoma endothelial cells
|Cid S,Eiro N,González LO,Beridze N,Vazquez J,Vizoso FJ||Clinical breast cancer (16:e83)||2016|
|Not Applicable||Not Cited||
A physical mechanism for coupling bone resorption and formation in adult human bone.
MA1-12894 was used in immunohistochemistry to investigate the molecular mechanism of bone remodeling with osteoclasts and osteoblasts
|Andersen TL,Sondergaard TE,Skorzynska KE,Dagnaes-Hansen F,Plesner TL,Hauge EM,Plesner T,Delaisse JM||The American journal of pathology (174:239)||2009|