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Product Details
66049-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2H6D8
Immunogen
MMS19 Fusion Protein Ag8960 (457-803 aa encoded by BC006575)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.98 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: FLDGNVSFL PENSFPSRFQ PFQDGSSGQR RLIALLMAFV CSLPRNVEIP QLNQLMRELL ELSCCHSCPF SSTAAAKCFA GLLNKHPAGQ QLDEFLQLAV DKVEAGLDSG PCRSQAFTLL LWVTKALVLR YHPLSSCLTA RLMGLLSDPE LGPAAADGFS LLMSDCTDVL TRAGHAEVRI MFRQRFFTDN VPALVQGFHA APQDVKPNYL KGLSHVLNRL PKPVLLPELP TLLSLLLEAL SCPDCVVQLS TLSCLQPLLL EAPQVMSLHV DTLVTKFLNL SSSPSMAVRI AALQCMHALT RLPTPVLLPY KPQVIRALAK PLDDKKRLVR KEAVSARGEW FLLGSPGS (457-803 aa encoded by BC006575)
Target Information
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hMMS19; homolog of yeast MMS19; incisor protein; MET18 homolog; MMS19 cytosolic iron-sulfur assembly component; MMS19 nucleotide excision repair homolog; MMS19 nucleotide excision repair protein homolog; MMS19 nucleotide excision repair-like; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein
Gene Aliases: 2410001K24Rik; 2610042O15Rik; AI316855; C79368; C86341; hMMS19; MET18; MMS19; MMS19L
UniProt ID: (Human) Q96T76, (Mouse) Q9D071
Entrez Gene ID: (Human) 64210, (Rat) 171124, (Mouse) 72199
Molecular Function:
scaffold/adaptor protein
phosphorelay signal transduction system
DNA metabolic process
DNA repair
nucleotide-excision repair
transcription, DNA-templated
cellular response to DNA damage stimulus
chromosome segregation
response to hormone
iron-sulfur cluster assembly
positive regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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