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MOB4A is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob4A regulates NDR1 and NDR2 kinase activity, widely expressed nuclear serine-threonine kinases that have been implicated in cell proliferation and/or tumor progression.
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Protein Aliases: MGC33910; MOB kinase activator 1B; Mob1 homolog 1A; MOB1 Mps One Binder homolog B; MOB1, Mps One Binder kinase activator-like 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A
Gene Aliases: MATS2; MOB1B; MOB4A; MOBKL1A
UniProt ID: (Human) Q7L9L4
Entrez Gene ID: (Human) 92597
Molecular Function: kinase activator