|Tested species reactivity||Cat, Human, Mouse, Non-human primate, Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Mouse / IgM|
|Immunogen||Glial membrane proteins followed by rat CNS white matter.|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 2 publications below|
MA1-21809 detects MOSP in Human, Rat, Mouse, Feline and Non-human primate samples.
MA1-21809 has been successfully used in Immunofluorescence and Immunohistochemistry (Frozen) procedures.
MA1-21809 immunogen corresponds to Glial membrane proteins followed by rat CNS white matter..
Myelin / Oligodendrocyte Specific Protein (MOSP) (pI of ~6.7) is found exclusively on oligodendrocytes and myelin in the central nervous system (CNS). Myelin is produced by oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system (PNS). Defining the differences between CNS and PNS myelin may provide insights into the process of myelination and the pathogenesis of certain idiopathic diseases involving myelin such as multiple sclerosis, certain leukodystrophies, and other myelinopathies. On demyelination, immunoreactivity for MOSP, like MBP, is lost.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Regional and cell-type specific distribution of HDAC2 in the adult mouse brain.
MA1-21809 was used in immunohistochemistry to study the expression of HDAC2 in adult murine brain
|Yao ZG,Zhang L,Huang L,Zhu H,Liu Y,Ma CM,Sheng SL,Qin C||Brain structure and function (218:563)||2013|
Treatment with metallothionein prevents demyelination and axonal damage and increases oligodendrocyte precursors and tissue repair during experimental autoimmune encephalomyelitis.
MA1-21809 was used in immunohistochemistry to study the effects of metallothionein treatment on demyelination, axonal damage, and tissue repair in an animal model of multiple sclerosis
|Penkowa M,Hidalgo J||Journal of neuroscience research (72:574)||2003|