Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
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Protein Aliases: CDG1B; mannose-6- phosphate isomerase; Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; phosphomannose isomerase 1; PMI
Gene Aliases: CDG1B; MPI; PMI; PMI1
UniProt ID: (Human) P34949
Entrez Gene ID: (Human) 4351
Molecular Function: isomerase