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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||PBS, pH 7.4|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:50-1:100|
|Immunohistochemistry (Frozen) (IHC (F))||1:500-1:5000|
|Immunohistochemistry (Paraffin) (IHC (P))||1:500-1:5000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
MA1-34067 detects MPO from human samples.
MA1-34067 has been successfully used in immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue) and Flow cytometry applications. A suggested positive control for this product is bone marrow.
The MA1-34067 immunogen is Human myeloperoxidase.
Store at 4°C short term. For extended storage, aliquot and store at -20°C, avoiding freeze/thaw cycles.
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1¿, IL-1ß, IL-12b, and CCL4 from differentiated HL-60 cells.
MA1-34067 was used in immunocytochemistry to elucidate the intracellular SNARE machinery responsible for the regulation of cytokine secretion and degranulation.
|Naegelen I,Plançon S,Nicot N,Kaoma T,Muller A,Vallar L,Tschirhart EJ,Bréchard S||Journal of leukocyte biology (97:557)||2015|