May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-type lectin domain family 13 member E; C-type mannose receptor 2; CD280; endocytic receptor (macrophage mannose receptor family); Endocytic receptor 180; Macrophage mannose receptor 2; mannose receptor, C type 2; UPAR-associated protein; Urokinase-type plasminogen activator receptor-associated protein
Gene Aliases: CD280; CLEC13E; ENDO180; KIAA0709; MRC2; UPARAP
UniProt ID: (Human) Q9UBG0
Entrez Gene ID: (Human) 9902
Molecular Function: receptor