|Immunohistochemistry (Paraffin) (IHC (P))||2 - 4 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 14 amino acid peptide from 2nd extracellular domain of human MRGPRX2 / MRGX2.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Orangutan, Monkey (100%) Chimpanzee, Gorilla, Gibbon, Marmoset (86%).
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein-coupled receptor MRGX2; Mas-related G protein-coupled receptor G3; Mas-related G-protein coupled receptor member X2; MAS-related GPR; MAS-related GPR, member X2; member X2; MRGPRX2; MRGX2
Gene Aliases: MGRG3; MRGPRX2; MRGX2
UniProt ID: (Human) Q96LB1
Entrez Gene ID: (Human) 117194
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