|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||Bacterial fusion protein of human MRP 2 containing residues 215-310.|
|Storage buffer||PBS with 1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:20|
|Western Blot (WB)||1:20-1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-26535 detects multidrug resistance associated protein 2 from human samples.
MA1-26535 has been successfully used in immunohistochemistry (frozen), ICC/IF, and Western blot procedures.
The MA1-26535 immunogen is a bacterial fusion protein of human MRP 2 containing residues 215-310.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.