Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
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Protein Aliases: 39S ribosomal protein L44, mitochondrial; l44; L44mt; Mitochondrial large ribosomal subunit protein mL44; RM44
Gene Aliases: COXPD16; L44MT; MRP-L44; MRPL44
UniProt ID: (Human) Q9H9J2
Entrez Gene ID: (Human) 65080
Molecular Function: endoribonuclease