Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: 28S ribosomal protein S11, mitochondrial; Cervical cancer proto-oncogene 2 protein; HCC-2; Mitochondrial small ribosomal subunit protein uS11m; MRP-S11
Gene Aliases: HCC-2; HCC2; MRP-S11; MRPS11; RPMS11; S11mt
UniProt ID: (Human) P82912
Entrez Gene ID: (Human) 64963
Molecular Function: ribosomal protein