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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The epitope recognized by this antibody maps to a region between residue 1300 and the C-terminus (residue 1360) of human MutS homolog 6 using the numbering given in entry NP_0001701|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||10-20 ug/ml|
|Immunofluorescence (IF)||10-20 µg/ml|
|Immunoprecipitation (IP)||2.5-5 µg/ml|
|Western Blot (WB)||0.5-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-31302 detects MSH6 from human samples.
PA1-31302 has been successfully used in immunoprecipitation, Western blot applications.
The PA1-31302 immunogen corresponds to a region between residue 1300 and the C-terminus (residue 1360) of human MutS homolog 6 using the numbering given in entry NP_0001701.
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; hMSH6; HNPCC5; HSAP; MutS-alpha 160 kDa subunit; p160; sperm-associated protein
GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160