Abnova

MSH6 Monoclonal Antibody (1F2)

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MSH6 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescence of monoclonal antibody to MSH6 on HeLa cell. Antibody concentration is 10 µg/mL.

MSH6 Antibody in Western Blot (WB) — MSH6 monoclonal antibody (M01), clone 1F2. Western Blot analysis of MSH6 expression in human kidney.

MSH6 Antibody in ELISA (ELISA) — Detection limit for recombinant GST tagged MSH6 is approximately 1 ng/mL as a capture antibody.

MSH6 Antibody in Proximity Ligation Assay (PLA) (PLA) — Proximity Ligation Analysis of protein-protein interactions between MSH2 and MSH6. HeLa cells were stained with anti-MSH2 rabbit purified polyclonal 1:1200 and anti-MSH6 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

Product Details

H00002956-M01

Applications	Tested Dilution	Publications
Western Blot (WB)	1-5 µg/mL	-
Immunocytochemistry (ICC/IF)	10 µg/mL	-
ELISA (ELISA)	1 ng/mL	-
in situ PLA (PLA)	1:1200	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG1, kappa
Class	Monoclonal
Type	Antibody
Clone	1F2
Immunogen	MSH6 (NP_000170, 931 a.a. approximately 1030 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	See Label
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.4
Contains	no preservative
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Sequence of this protein is as follows: AGFDSDYDQA LADIRENEQS LLEYLEKQRN RIGCRTIVYW GIGRNRYQLE IPENFTTRNL PEEYELKSTK KGCKRYWTKT IEKKLANLIN AEERRDVSLK

Target Information

The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; hMSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS protein homolog 6; MutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein; sperm-associated protein

Gene Aliases: GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160

UniProt ID: (Human) P52701

Entrez Gene ID: (Human) 2956

Molecular Function: DNA metabolism protein