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Product Details
UM800148
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
UMAB258 |
Immunogen |
Human recombinant protein fragment corresponding to amino acids 1-280 of human MSH6 produced in E.coli. |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
0.5-1.0 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 1% BSA, 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Target Information
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; hMSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS protein homolog 6; MutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein; sperm-associated protein
Gene Aliases: GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160
UniProt ID: (Human) F5H2F9
Entrez Gene ID: (Human) 2956
Molecular Function:
DNA metabolism protein
meiotic mismatch repair
DNA repair
mismatch repair
reciprocal meiotic recombination
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
viral process
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
isotype switching
positive regulation of isotype switching
negative regulation of DNA recombination
positive regulation of helicase activity
intrinsic apoptotic signaling pathway
magnesium ion binding
four-way junction DNA binding
chromatin binding
double-stranded DNA binding
protein binding
ATP binding
ATPase activity
mismatched DNA binding
guanine/thymine mispair binding
single guanine insertion binding
single thymine insertion binding
oxidized purine DNA binding
MutLalpha complex binding
methylated histone binding
protein homodimerization activity
ADP binding
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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